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Virtual Pediatric Hospital: Paediapaedia: Hypothyroidism Paediapaedia: Musculoskeletal Diseases

Hypothyroidism

Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed


Clinical Presentation:
Short status and psychomotor retardation.

Etiology/Pathophysiology:
Thyroid hormone deficiency.

Pathology:
Not applicable

Imaging Findings:
Marked delay in the appearance of ossification centers and skeletal maturation. Skeletal maturation, when measured by bone age, is usually 4 standard deviations below the mean for chronologic age. When the epiphyses appear they are dysplastic and fragmented due to slow endochondral bone formation. There can be multiple wormian bones in the skull.

DDX:

References:
See References Chapter.

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