Osteopetrosis

Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed

Etiology/Pathophysiology:
Have a persistently calcified cartilaginous matrix, poorly formed and absent medullary cavities, poorly differentiated compact bone, and spongiosa that is solid bone.

Pathology:
Not applicable

Imaging Findings:
On plain film homogeneous increased bone density is seen. The bones have a marbled appearance and sometimes can have a "bone within a bone" appearance. The lower extremities have a lack of normal metaphyseal tubularization causing club shaped metaphyses, and there arcuate bands of increased bone density around iliac wings.The paranasal sinuses are often obliterated

DDX:
Generalized osteosclerosis:

• Pycnodysostosis
• Diaphyseal dysplasia (Engel MannÕs)
• Craniodiaphyseal dysplasia
• Metaphyseal dysplasia (Pyle)
• Frontometaphyseal dysplasia
• Craniometaphyseal dysplasia
• Dysosteosclerosis
• Heavy metal intoxication
• Hypervitaminosis D
• Hypothyroidism
• Congenital syphilis
• Normal sclerosis

References:
See References Chapter.

Section Top | Title Page

URL: http://www.virtualpediatrichospital.org/