Additional pediatric resources: GeneralPediatrics.com | PediatricEducation.org | SearchingPediatrics.com
Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed
Etiology/Pathophysiology:
Secondary to maternal and transplacental transmission of infection.
Occurs during the second or third trimester. Seventy-five percent of
cases have bone involvement but it may not be present at birth
because skeletal lesions take 6- 8 weeks to develop from the time of
infection.
Pathology:
Not applicable
Imaging Findings:
First thing seen in bones is abnormalities in bone mineralization
caused by systemic infection and only later does the bone actually
become infected and at this time you see bone destruction and
periosteal new bone formation. Wimberger's sign is bilateral focal
destruction of the proximal medial tibial metaphyses. See also ill
defined translucent linear bands in the metaphyses.
DDX:
References:
See References Chapter.
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